昨天，"像風一樣的男子"林醫師
突然注意到我跟學長的存在
就在他大肆地談論"同居"的觀念之後...
"那麼warfarin跟誰有交互作用?"
醫師見intern沒反應後，就說"這種問題要問藥劑的才對!"
"哪種藥跟warfarin會有交互作用..而且重點是!該類藥是神內常用的藥喔!"
我的腦~運轉~再運轉~
想了帕金森的用藥~
又想了阿茲海默的用藥~
...........但沒有回答到醫師想要的那個答案~
正確答案是.....
Statin!!!!!!
我冷汗直流.....神經科常用藥物.....我都只想到帕金森~阿茲海默~statin...好遙遠~
以下是來自於CCIS的資料~供大家參考
1.Fluvastatin
(1)Interaction Effect: an increased risk of bleeding
(2)Severity: moderate
(3)Probable Mechanism: increased warfarin serum concentrations due to inhibition of CYP2C9-
mediated S-warfarin metabolism
2.Lovastatin
(1)Interaction Effect: an increased risk of bleeding
(2)Severity: moderate
(3)Probable Mechanism: unknown
3.Rosuvastatin
(1)Interaction Effect: increase in international normalized ration (INR) and increased risk of bleeding
(2)Severity: moderate
(3)Probable Mechanism: unknown
4.Simvastatin
(1)Interaction Effect: increased risk of bleeding and an increased risk of rhabdomyolysis
(2)Severity: moderate
(3)Probable Mechanism: competition for cytochrome P450 3A4-mediated metabolism
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